ТHE METABOLIC ASPECTS OF PREECLAMPSIA DEVELOPMENT
نویسندگان
چکیده
Complications associated with preeclampsia (PE) include fetal growth retardation, premature birth, prenatal and postpartum hemorrhage, perinatal loss, more. Obese women have an increased risk of developing PE, probably due to impaired placental development altered metabolic homeostasis. The aim was generalize current knowledge about the role factors obesity hypercholesterolemia in PE emphasis on results preclinical models. Material methods. In reviewing literature, we used Medline systems from PubMed (2011). search adapted for Embase (2014-2022) Scopus (2015-2022). inclusion criteria were: effect pregnancy; experimental models pathogenesis during features predictive diagnosis obese at stage preconception antenatal care women. study performed Vinnytsya National Pirogov Memorial Medical University, according research work № 0121U109141 “Optimization early preventive treatment complications caused by gestational endotheliopathy.” Results. Inflammatory cytokines maternal adipose tissue been systemic inflammation, hypertension, other adverse effects PE. main pathways negative influence genesis were realized manifested endotheliopathy. Decreases adipokines optimization angiogenesis overall improvement Conclusions. Increased mass cholesterol levels contribute disorders which may endotheliopathy subsequent abnormal placenta vascularization. Further will need further clarify contribution pharmacotherapy, as well some lifestyle adjustments, including preconceptional weight loss high obesity.
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ژورنال
عنوان ژورنال: Zbìrnik naukovih prac? Asocìacìï akušerìv-gìnekologìv Ukraïni
سال: 2022
ISSN: ['2707-1677', '2664-0767']
DOI: https://doi.org/10.35278/2664-0767.1(49).2022.266320